Smart-Pill Tracking in the Gut

Team Members: Saransh Sharma, Khalil B. Ramadi, Nikhil H. Poole, Shriya S. Srinivasan, Keiko Ishida, Johannes Kuosmanen, Josh Jenkins, Fatemeh Aghlmand, Margaret B. Swift, Mikhail G. Shapiro, Giovanni Traverso, Azita Emami The advancement in medical technology has led to the development of innovative diagnostic and treatment methods for gastrointestinal (GI) disorders. A key area of […]

Wireless Surgical Navigation

Team Members: Saransh Sharma, Azita Emami In our groundbreaking project, we have successfully developed a state-of-the-art radiation-free system specifically designed to enhance the accuracy and safety of various precision surgical procedures. This innovative system is engineered for high-precision alignment, navigation, and tracking of both sensors and surgical tools, offering a revolutionary alternative to traditional methods. […]

3D CMOS Magnetic Sensor

Team Members: Saransh Sharma The 3D CMOS Magnetic Sensor represents a significant advancement in the field of magnetic sensing, which is integral to a wide array of applications across various industries, including automotive, navigation, medical electronics, and consumer products. Traditional Hall sensors, though compatible with CMOS technology, often grapple with issues such as subpar sensitivity […]

CMOS Fluorescence Sensor

Team Members: Fatima Aghlmand, Saransh Sharma The development of a novel “Cell-Silicon” system, which fuses silicon chip technology with live bacterial biosensors, presents groundbreaking possibilities in the realms of smart medicine and environmental monitoring. This integrated approach aims to harness the unique capabilities of both silicon-based and biological sensing elements, thereby opening the door to […]

Wearable Biosensor for Fatigue Monitoring

Team Members: Saransh Sharma To effectively monitor the health and performance of military personnel under challenging conditions such as extreme weather, resource scarcity, unsanitary environments, and exposure to exotic diseases, we propose the development of an advanced wearable biosensor patch. This innovative device is designed to continuously track a comprehensive range of biomarkers directly from […]


3D Nvigation for High-Precision Surgery

A 3D localization system using magnetic field gradients that can replace X-Ray fluoroscopy in high precision surgery has been developed by our team. Monotonically varying magnetic fields encode spatial points uniquely in the field-of-view and are sensed by miniaturized devices with wireless power and data telemetry. Relative device locations are displayed in real-time. A prototype system consisting of a 65nm CMOS chip and gradient coils achieves a localization error of <100µm in 3D when tested in-vitro.

Location-Broadcasting Chips

We present an alternative approach to microscale device localization based on concepts from nuclear magnetic resonance. In particular, the magnetic-field-dependent precession frequency of nuclear spins allows their location in space to be encoded through the application of magnetic field gradients. This allows MRI to visualize signals from nuclear spins located throughout a specimen with ~100 µm resolution.

Fully Implantable Glucose and Lactate Sensor

Miniaturization of implantable biosensors for continuous, in vivo monitoring of clinically relevant analytes is an important step toward viability of such devices. While wireless power delivery via on-chip antennas promises miniaturization and realization of minimally invasive devices, it can only support low levels of power consumption. This is due to the significant tissue absorption at high frequencies, small size of the chip and quality factor of on-chip inductors. Therefore, reducing the power consumption of the sensor while maintaining high sensitivity and dynamic range is crucial.

Circuits for Biological and Medical Systems

Retinal Prosthesis

Most progressive vision loss occurs when the first layer of the retina (the photoreceptors) is damaged. Retinal prostheses aim to restore vision by bypassing the damaged photoreceptors and directly stimulating the remaining healthy neurons. Our approach uses highly scaled technologies to reduce area and power, and to support hundreds of channels for fully intraocular implants.

Origami Biomedical Implants

Origami implant design is a 3D integration technique which addresses the size and cost constraints in biomedical implants. Large systems can be split into multiple chips and connected using 3D integration techniques to be folded compactly for implantation and unfolded inside the body. Electronics can be partitioned into functional blocks for mass-production and customs implants can be assembled from these relatively cheap modules.